Scientific Record

Publications

38 peer-reviewed papers (2021–2026) across oncology, metabolism, and cell biology.

2026
2026
KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition.
Chen N, Fang M, Zhong L, Li X, Zhou Y, Zhan J, Wang M, Fang Z, Wang H, Tang S, Liu F, Deng B, Chen N, Lei J, Zhang Y, Yan M, Zou Z, Gao Y, Chen C, Zhong W, Saladi S, Ji H, Liu Q, Wang Z, He B
Cell Death and Differentiation · 33(7): 1416–1435 · DOI: 10.1038/s41418-025-01657-7
2026
NPM1 mutation promotes creatine anabolism by FTO-dependent m6A demethylation to drive macrophage M2 polarization in acute myeloid leukemia.
Wang J, Liao C, Lei X, Peng Z, Lin Z, Liu J, Liu Q, Zhang L, Long Z
Cancer Letters · 657: 218637 · DOI: 10.1016/j.canlet.2026.218637
2025
2025
Bridging Psychoneuroimmunology (PNI) and Cancer: New Insights and Innovations from China.
Yan M, Kelley K, Liu Q
Brain, Behavior, and Immunity-Integrative · 10: 100125 · DOI: 10.1016/j.bbii.2025.100125
2025
Integrating Cancer Medicine into Metabolic Rhythms.
Su K, Zeng D, Zhang W, Peng F, Cui B, Liu Q
Trends in Endocrinology & Metabolism · 36(11): 1014–1028 · DOI: 10.1016/j.tem.2025.03.007
2025
Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.
Long L, Zhang B, Peng W, Pan Y, Zhai H, Cheng B, Tu Z, Long Z, Zhou H, Liu Q, Lu G
Journal of Medicinal Chemistry · 68(17): 18197–18215 · DOI: 10.1021/acs.jmedchem.5c00107
2025
SLIT3-Mediated Intratumoral Crosstalk Induces Neuroblastoma Differentiation via a Spontaneous Regression-like Program.
Liu M, Lv D, Yan W, Wu Y, Wang S, Wang L, Lei J, Zeng D, Wang Z, Liu F, Deng B, Liu Q, He B, Yan M
Journal of Translational Medicine · 23(1): 598 · DOI: 10.1186/s12967-025-06621-0
2025
Senescent-like Border-Associated Macrophages Regulate Cognitive Aging via Migrasome-Mediated Induction of Paracrine Senescence in Microglia.
Hu M, Kang X, Liu Z, Wang S, Liu S, Li C, Lu D, Qin Q, Liu Y, Yi H, Yuan L, Liu Q, Lu Z, Cai W
Nature Aging · 5(10): 2039–2054 · DOI: 10.1038/s43587-025-00956-5
2025
Crosstalk between Lipid Metabolism and EMT: Emerging Mechanisms and Cancer Therapy.
Ud Din Z, Cui B, Wang C, Zhang X, Mehmood A, Peng F, Liu Q
Molecular and Cellular Biochemistry · 480(1): 103–118 · DOI: 10.1007/s11010-024-04995-1
2025
Gut Dysbiosis Conveys Psychological Stress to Activate LRP5/β-Catenin Pathway Promoting Cancer Stemness.
Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley K, Xu G, Xu L, Liu Q, Peng F
Signal Transduction and Targeted Therapy · 10(1): 79 · DOI: 10.1038/s41392-025-02159-1
2024
2024
Aurora Kinase A-Mediated Phosphorylation Triggers Structural Alteration of Rab1A to Enhance ER Complexity during Mitosis.
Zhang W, Zhang Z, Xiang Y, Gu D, Chen J, Chen Y, Zhai S, Liu Y, Jiang T, Liu C, He B, Yan M, Wang Z, Xu J, Cao Y, Deng B, Zeng D, Lei J, Zhuo J, Lei X, Long Z, Jin B, Chen T, Li D, Shen Y, Hu J, Gao S, Liu Q
Nature Structural & Molecular Biology · 31(2): 219–231 · DOI: 10.1038/s41594-023-01165-7
2024
Oncogenic Fatty Acid Oxidation Senses Circadian Disruption in Sleep-Deficiency-Enhanced Tumorigenesis.
Peng F, Lu J, Su K, Liu X, Luo H, He B, Wang C, Zhang X, An F, Lv D, Luo Y, Su Q, Jiang T, Deng Z, He B, Xu L, Guo T, Xiang J, Gu C, Wang L, Xu G, Xu Y, Li M, Kelley K, Cui B, Liu Q
Cell Metabolism · 36(7): 1598–1618 · DOI: 10.1016/j.cmet.2024.04.018
2024
Olanzapine Suppresses mPFC Activity-Norepinephrine Releasing to Alleviate CLOCK-Enhanced Cancer Stemness under Chronic Stress.
Lu J, Zhang X, Su K, Luo H, Liu C, Yang Y, He B, Wang C, Zhao Z, Liu X, Wang X, Meng P, Lv D, Wang C, Kelley K, Wang L, Cui B, Liu Q, Peng F
Cell Communication and Signaling · 22(1): 375 · DOI: 10.1186/s12964-024-01747-y
2024
EP300-ZNF384 Transactivates IL3RA to Promote the Progression of B-Cell Acute Lymphoblastic Leukemia.
Hou Z, Ren Y, Zhang X, Huang D, Yan F, Sun W, Zhang W, Zhang Q, Fu X, Lang Z, Chu C, Zou B, Gao B, Jin B, Kang Z, Liu Q, Yan J
Cell Communication and Signaling · 22(1): 211 · DOI: 10.1186/s12964-024-01596-9
2024
AURKA Emerges as a Vulnerable Target for KEAP1-Deficient Non-Small Cell Lung Cancer by Activation of Asparagine Synthesis.
Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell Death & Disease · 15(3): 233 · DOI: 10.1038/s41419-024-06577-x
2023
2023
Single-Cell Heterogeneity and Dynamic Evolution of Ph-like Acute Lymphoblastic Leukemia Patient with Novel TPR-PDGFRB Fusion Gene.
Zhang X, Hou Z, Huang D, Wang F, Gao B, Zhang C, Zhou D, Lou J, Wang H, Gao Y, Kang Z, Lu Y, Liu Q, Yan J
Experimental Hematology & Oncology · 12(1): 19 · DOI: 10.1186/s40164-023-00380-8
2023
Low-Density Lipoprotein Receptor Promotes Crosstalk between Cell Stemness and Tumor Immune Microenvironment in Breast Cancer: A Large Data-Based Multi-Omics Study.
Yuan Q, Lu X, Guo H, Sun J, Yang M, Liu Q, Tong M
Journal of Translational Medicine · 21(1): 871 · DOI: 10.1186/s12967-023-04699-y
2023
The Nature of Cancer.
Yan M, Liu Q
Frontiers of Medicine · 17(4): 796–803 · DOI: 10.1007/s11684-022-0975-5
2023
Cancer Cell Employs a Microenvironmental Neural Signal Trans-Activating Nucleus-Mitochondria Coordination to Acquire Stemness.
He B, Gao R, Lv S, Chen A, Huang J, Wang L, Feng Y, Feng J, Liu B, Lei J, Deng B, He B, Cui B, Peng F, Yan M, Wang Z, Lam E, Jin B, Shao Z, Li Y, Jiao J, Wang X, Liu Q
Signal Transduction and Targeted Therapy · 8(1): 275 · DOI: 10.1038/s41392-023-01487-4
2023
Pyrroline-5-Carboxylate Reductase 1 Reprograms Proline Metabolism to Drive Breast Cancer Stemness under Psychological Stress.
Cui B, He B, Huang Y, Wang C, Luo H, Lu J, Su K, Zhang X, Luo Y, Zhao Z, Yang Y, Zhang Y, An F, Wang H, Lam E, Kelley K, Wang L, Liu Q, Peng F
Cell Death & Disease · 14(10): 682 · DOI: 10.1038/s41419-023-06200-5
2023
STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia.
Huang Z, Zhang X, Zhang L, Liu L, Zhang J, Sun Y, Xu J, Liu Q, Long Z
Signal Transduction and Targeted Therapy · 8(1): 391 · DOI: 10.1038/s41392-023-01605-2
2023
Dietary γ-mangostin triggers immunogenic cell death and activates cGAS signaling in acute myeloid leukemia.
Long Z, Wang J, Qiu S, Zhang Y, Wu S, Lei X, Huang Z, Chen J, Yang Y, Zhang X, Liu Q
Pharmacological Research · 197: 106973 · DOI: 10.1016/j.phrs.2023.106973
2022
2022
Fine-Tuning Cell Organelle Dynamics during Mitosis by Small GTPases.
Zhang Z, Zhang W, Liu Q
Frontiers of Medicine · 16(3): 339–357 · DOI: 10.1007/s11684-022-0926-1
2022
VLDLR Disturbs Quiescence of Breast Cancer Stem Cells in a Ligand-Independent Function.
Yang M, Zhan Y, Hou Z, Wang C, Fan W, Guo T, Li Z, Fang L, Lv S, Li S, Gu C, Ye M, Qin H, Liu Q, Cui X
Frontiers in Oncology · 12: 887035 · DOI: 10.3389/fonc.2022.887035
2022
DNA Damage-Induced Paraspeckle Formation Enhances DNA Repair and Tumor Radioresistance by Recruiting Ribosomal Protein P0.
Wang Y, Zhao W, Bai S, Ma Y, Yin X, Feng L, Zeng G, Wang F, Feng W, Zheng J, Wang Y, Zeng B, Liu Q, Hung M, Wan X
Cell Death & Disease · 13(8): 709 · DOI: 10.1038/s41419-022-05092-1
2022
A Temporal PROTAC Cocktail-mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells.
Liu F, Wang X, Duan J, Hou Z, Wu Z, Liu L, Lei H, Huang D, Ren Y, Wang Y, Li X, Zhuo J, Zhang Z, He B, Yan M, Yuan H, Zhang L, Yan J, Wen S, Wang Z, Liu Q
Advanced Science · 9(22): 2104823 · DOI: 10.1002/advs.202104823
2022
Nuclear Aurora Kinase A Switches m6A Reader YTHDC1 to Enhance an Oncogenic RNA Splicing of Tumor Suppressor RBM4.
Li S, Qi Y, Yu J, Hao Y, He B, Zhang M, Dai Z, Jiang T, Li S, Huang F, Chen N, Wang J, Yang M, Liang D, An F, Zhao J, Fan W, Pan Y, Deng Z, Luo Y, Guo T, Peng F, Hou Z, Wang C, Zheng F, Xu L, Xu J, Wen Q, Jin B, Wang Y, Liu Q
Signal Transduction and Targeted Therapy · 7(1): 97 · DOI: 10.1038/s41392-022-00905-3
2022
A Microfluidic Demonstration of "Cluster-Sprout-Infiltrating" Mode for Hypoxic Mesenchymal Stem Cell Guided Cancer Cell Migration.
An F, Hou Z, Wang X, Wang Z, Jing C, Sui R, Wu Y, Ma Y, Chang C, Liu S, Li M, Sun L, Gao Z, Zhang W, Lang Z, Zhao J, Qu Y, Xu L, Luo Y, Yan J, Wang Y, Xu J, Liu Q
Biomaterials · 290: 121848 · DOI: 10.1016/j.biomaterials.2022.121848
2022
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy.
Long Z, Wang J, Xu J, Lei X, Liu Q
Molecular Therapy · 30(3): 1006–1017 · DOI: 10.1016/j.ymthe.2022.01.044
2021
2021
Modulation of Oxidative Phosphorylation Augments Antineoplastic Activity of Mitotic Aurora Kinase Inhibition.
Zhang Z, Zeng D, Zhang W, Chen A, Lei J, Liu F, Deng B, Zhuo J, He B, Yan M, Lei X, Wang S, Lam E, Liu Q, Wang Z
Cell Death & Disease · 12(10): 893 · DOI: 10.1038/s41419-021-04190-w
2021
Targeting Cancer Cell Plasticity by HDAC Inhibition to Reverse EBV-Induced Dedifferentiation in Nasopharyngeal Carcinoma.
Xie J, Wang Z, Fan W, Liu Y, Liu F, Wan X, Liu M, Wang X, Zeng D, Wang Y, He B, Yan M, Zhang Z, Zhang M, Hou Z, Wang C, Kang Z, Fang W, Zhang L, Lam E, Guo X, Yan J, Zeng Y, Chen M, Liu Q
Signal Transduction and Targeted Therapy · 6(1): 333 · DOI: 10.1038/s41392-021-00702-4
2021
Construction of a Microenvironment Immune Gene Model for Predicting the Prognosis of Endometrial Cancer.
Wang Y, Zhang J, Zhou Y, Li Z, Lv D, Liu Q
BMC Cancer · 21(1): 1203 · DOI: 10.1186/s12885-021-08935-w
2021
Nuclear Aurora Kinase A Triggers Programmed Death-ligand 1-mediated Immune Suppression by Activating MYC Transcription in Triple-negative Breast Cancer.
Sun S, Zhou W, Li X, Peng F, Yan M, Zhan Y, An F, Li X, Liu Y, Liu Q, Piao H
Cancer Communications · 41(9): 851–866 · DOI: 10.1002/cac2.12190
2021
Oncogenic AURKA-Enhanced N6-Methyladenosine Modification Increases DROSHA mRNA Stability to Transactivate STC1 in Breast Cancer Stem-like Cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam E, Liu Q
Cell Research · 31(3): 345–361 · DOI: 10.1038/s41422-020-00397-2
2021
Cancer Cell Immune Mimicry Delineates Onco-Immunologic Modulation.
Gao R, He B, Huang Q, Wang Z, Yan M, Lam E, Lin S, Wang B, Liu Q
iScience · 24(10): 103133 · DOI: 10.1016/j.isci.2021.103133
2021
Cancer and Stress: NextGen Strategies.
Cui B, Peng F, Lu J, He B, Su Q, Luo H, Deng Z, Jiang T, Su K, Huang Y, Ud Din Z, Lam E, Kelley K, Liu Q
Brain, Behavior, and Immunity · 93: 368–383 · DOI: 10.1016/j.bbi.2020.11.005
2021
Allele Frequency Deviation (AFD) as a New Prognostic Model to Predict Overall Survival in Lung Adenocarcinoma (LUAD).
Al-Dherasi A, Liao Y, Al-Mosaib S, Hua R, Wang Y, Yu Y, Zhang Y, Zhang X, Jalayta R, Mousa H, Al-Danakh A, Alnadari F, Almoiliqy M, Baldi S, Shi L, Lv D, Li Z, Liu Q
Cancer Cell International · 21(1): 451 · DOI: 10.1186/s12935-021-02127-z
2021
A Seven-Gene Prognostic Signature Predicts Overall Survival of Patients with Lung Adenocarcinoma (LUAD).
Al-Dherasi A, Huang Q, Liao Y, Al-Mosaib S, Hua R, Wang Y, Yu Y, Zhang Y, Zhang X, Huang C, Mousa H, Ge D, Sufiyan S, Bai W, Liu R, Shao Y, Li Y, Zhang J, Shi L, Lv D, Li Z, Liu Q
Cancer Cell International · 21(1): 294 · DOI: 10.1186/s12935-021-01975-z
2021
CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer.
Chen A, Wen S, Liu F, Zhang Z, Liu M, Wu Y, He B, Yan M, Kang T, Lam E, Wang Z, Liu Q
Cancer Communications · 41(2): 121–139 · DOI: 10.1002/cac2.12125